Single-cell RNA-seq of motor cortex in a mouse model of alpha-synuclein pathologyThis dataset was created with the goal of identifying transcriptomic changes associated with alpha-synuclein pathology in the alpha-synuclein fibril seeding mouse model. The dataset includes single cell RNA Sequencing data from motor cortex of mice injected with alpha-synuclein pre-formed fibrils ("PFF" group) or alpha-synuclein monomer as controls ("Control" group). The dataset includes subject cohorts with different levels of the following additional experimental factors: sex (male or female); brain hemisphere relative to the PFF injection site (ipsilateral or contralateral); time post-injection (1, 3, 6, or 9 months post-injection). ASAP Team: Biederer Dataset Name: biederer-mouse-sc-rnaseq, v1.0 Principal Investigator: Thomas Biederer Co-Principal Investigator: Elena Gracheva Contributors: Feketa, Viktor; Gracheva, Elena; Henderson, Michael; Breton, Elizabeth; Meyerdirk, Lindsay; Volpicelli-Daley, Laura; Menard, Marissa; Biederer, Thomas Sample Summary: Resources and Additional Information Protocols GitHub: https://github.com/viktorfeketa/asap Protocols: https://dx.doi.org/dx.doi.org/10.17504/protocols.io.q26g74by3gwz/v1 Dataset DOI: https://doi.org/10.5281/zenodo.15485103...Access requires approval by the data custodian. The collection's description and structure are public; querying the data requires an approved request.Single-cell RNA-seq of motor cortex in a mouse model of alpha-synuclein pathology is published on ASAP CRN Cloud.