Single-nucleus RNA-seq of the striatum of two mouse Parkinson's disease modelsThis dataset includes single-nucleus RNA sequencing (snRNA-seq) data derived from mouse models of Parkinson's disease (PD), designed to capture both cell-type-specific and spatial gene expression changes across different stages and mechanisms of PD-like pathology. Single-nucleus RNA sequencing (snRNA-seq) was performed on mouse striatal tissue from two distinct PD models: 1. Mild Neurotoxin Model (6-OHDA): Adult wild-type mice received unilateral injections of 6-hydroxydopamine (6-OHDA) at a low dose (0.6 µg/µL) into the medial forebrain bundle (MFB), selectively damaging nigrostriatal dopaminergic neurons and inducing mild Parkinsonian pathology. Untreated wild-type mice served as controls. 2. Progressive Genetic Model (MitoPark): The MitoPark model (Slc6a3-cre; Tfam^flx/flx) induces mitochondrial dysfunction specifically in dopaminergic neurons, leading to progressive neurodegeneration. Samples were collected at two timepoints: * 10–11 weeks of age: Early stage, pre-symptomatic or mildly affected, and * 15–18 weeks of age: Late stage, with clear motor deficits and advanced degeneration. This snRNA-seq dataset enables in-depth analysis of transcriptomic alterations across...Access requires approval by the data custodian. The collection's description and structure are public; querying the data requires an approved request.Single-nucleus RNA-seq of the striatum of two mouse Parkinson's disease models is published on ASAP CRN Cloud.