G2019S LRRK2 knockin mice and their wild-type littermates were maintained on a normal chow diet (23.7% kcal from fat) for the first 11 months of life. At that time, animals were randomly assigned to either a high-fat diet group (60% kcal from fat) or a control diet group (10% kcal from fat). Mice remained on their respective diets for an additional five months. At 16 months of age, striatal tissue was collected for bulk RNA-seq analysis. Each experimental group contained biological replicates (n = 4 per group). ASAP Team: Lee Dataset Name: lee-mouse-bulk-rnaseq-striatum-g2019s-hf-diet, v1.0 Principal Investigator: Michael Lee Co-Principal Investigator: Darren Moore Contributors: Ma, Yue; Moore, Darren Sample Summary: Resources and Additional Information Protocols GitHub: https://doi.org/10.5281/zenodo.15651884 Protocols: https://doi.org/10.17504/protocols.io.eq2ly43kwlx9/v1 Dataset DOI: https://doi.org/10.5281/zenodo.18273802 Associated Publications: https://doi.org/10.1038/s41531-026-01465-x CRN Cloud GitHub: https://github.com/ASAP-CRN CRN Cloud DOI: https://doi.org/10.5281/zenodo.8384742 CRN Cloud Data Dictionary:...
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Bulk RNA-seq analysis of the striatum in G2019S LRRK2 knockin mice under a specialized diet is published on ASAP CRN Cloud.